Hassan Fazilaty

Research Associate

Dr. Hassan Fazilaty

Office Y55-L-70

Tel +41 44 635 31 26

Brief CV

01.2024-present, Research associate, Lab of Professor Konrad Basler, Institute of Molecular Life Sciences, University of Zurich, Zurich, Switzerland

08.2019-12.2023, Postdoctoral fellow, Lab of Professor Konrad Basler, Institute of Molecular Life Sciences, University of Zurich, Zurich, Switzerland

04.2019-08.2019, Postdoctoral researcher, Lab of Professor M. Angela Nieto, Instituto de Neurociencias CSIC-UMH, San Juan de Alicante, Spain

09.2014-04.2019, Doctor of Philosophy (Ph.D.), Lab of Professor M. Angela Nieto, Instituto de Neurociencias CSIC-UMH, San Juan de Alicante, Spain &  School of Medicine, Universidad Autonoma de Madrid (UAM), Madrid, Spain

09.2011-08.2014, Master of Science (M.Sc.) in Human Genetics, Department of Medical Genetics, Tehran University of Medical Sciences (TUMS), Tehran, Iran

Outreach

02.09.2023, Scientifica, University of Zurich, Zurich, Switzerland, short lecture:
Hijacked and Reprogrammed by Cancer Cells - Scientifica

Fellowship/funding

06.2024-12.2024, GRC career grant (2024_Q1_CG_001) to Hassan Fazilaty, University of Zurich, Switzerland

01.2023-12.2025, 3RCC grant (3Rs Doctorate Program: DP-2022-003) to Tosca Dalessi, Hassan Fazilaty, Tomas Valenta and Konrad Basler, Switzerland

12.2021-11.2021, Forschungskredit Postdoc fellowship, University of Zurich, Switzerland

08.2021, 2 years 3RCC grant (Project OC-2020-011) to Jamie Little, Konrad Basler, Erich Brunner and Hassan Fazilaty, Switzerland

11.2019-11.2021, 2 years fellowship of Cancer Research Center Zurich (CRC funding) to Prof. Konrad Basler and Prof. Gerhard Rogler, University of Zurich (UZH) and University Hospital Zurich (USZ), Switzerland

09.2014-08.2017, 3 years fellowship award, Santiago Grisolia (GRISOLIA / 2014/004) Resolution of 3 June 2014, Generalitat Valenciana, Spain

08.2013, Grant # 92003378 from Iran National Science Foundation (INSF) to Dr. Babak Behnam and Hassan Fazilaty, Iran

06.2013, Grant from Iran University of Medical Sciences (IUMS) to Dr. Babak Behnam and Hassan Fazilaty, Iran

Selected Publications

Dalessi T, Valenta T, Moro G, Brügger MD, Meijs A, Szczerba BM, Brunner T, Lampart S, Nater M, van den Broek M, Platt RJ, Scharl M and Fazilaty H*. An oncoembryology approach uncovers SoxC-driven regulation of colon development and cancer. bioRxiv 2024 |https://10.1101/2024.10.08.617191.

Youssef KK, Narwade N, Arcas A, Marquez-Galera A, Jiménez-Castaño R, Lopez-Blau C, Fazilaty H ... and Nieto MA*. Two distinct epithelial-tomesenchymal transition programs control invasion and inflammation in segregated tumor cell populations. Nature Cancer 2024 |https://10.1038/s43018-024-00839-5.

Borrelli C, Roberts M, Eletto D. Hussherr MD, Fazilaty H, Valenta T ... and Moor AE*. In vivo interation screening reveals liver-derived constraints to metastasis. Nature 2024 632:411–418 |https://10.1038/s41586-024-07715-3.

Fazilaty H* and Basler K. Reactivation of embryonic genetic programs in tissue regeneration and disease. Nature Genetics 2023 55:1792-1806 |https://10.1038/s41588-023-01526-4.

Berková L, Fazilaty H, Yang Q, Kubovciak J, Stastna M. Hrckulak D, Vojtechova M, Dalessi T, Brügger MD, Hausmann G, Liberal P, Korinek V, Basler K and Valenta T*. Terminal differentiation of villus-tip enterocytes is governed by distinct TGFβ superfamily members. EMBO Reports 2023 24:e56454 |https://10.15252/embr.202256454.

Fazilaty H*. Restoration of embryonic gene expression patterns in tissue regeneration and disease. Nat Rev Mol Cell Biol 2023 24:375-376 |https://10.1038/s41580-023-00586-y.

Fazilaty H#, Brügger M#, Valenta T#, Szczerba BM, Berkova L, Doumpas N, Hausmann G, Scharl M and Basler K*. Tracing colonic embryonic transcriptional profile and tracking their reactivation in inflammatory disease at single cell level. Cell Reports 2021 36:109484   |https://doi.org/10.1016/j.celrep.2021.109484.

Brügger M#, Valenta T#, Fazilaty H#, Hausmann G and Basler K*. Distinct populations of crypt-associated fibroblasts act as signaling hubs to control colon homeostasis. Plos Biology 2020 18:e3001032 |https://doi.org/10.1371/journal.pbio.3001032.

Fazilaty H, Rago L, Youssef KK, Ocana O, Garcia-Asencio F, Arcas A, Galceran J and Nieto MA*. A Gene Regulatory Network to Control EMT Programs in Development and Disease. Nature Communications 2019 10:5115  |https://doi.org/10.1038/s41467-019-13091-8.

Rago L, Castroviejo N, Fazilaty H, Garcia-Asencio F, Galceran J and Nieto MA*. MicroRNAs establish the right-handed dominance of the heart laterality pathway in vertebrates. Developmental Cell 2019 51:446-459.e5 | https://doi.org/10.1016/j.devcel.2019.09.012.

Fazilaty H, Gardaneh M, Akbari P, Zekri A and Behnam B*. SLUG and SOX9 cooperatively regulate metastatic niche factors in breast cancer. Cancer Microenvironment 2015 9:71-74 https://doi.org/10.1007/s12307-015-0176-8.

Fazilaty H, Gardaneh M, Bahrami T, Salmaninejad A and Behnam B*. Crosstalk between breast cancer stem cells and metastatic niche: emerging molecular metastasis pathway? Tumor Biology 2013 34:2019-2030 |https://doi.org/10.1007/s13277-013-0831-y.

#Equal contribution.
*Corresponding author.

PubMed link: https://pubmed.ncbi.nlm.nih.gov/?term=fazilaty+h&sort=date