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Stepwise virus assembly in the cell nucleus revealed by spatiotemporal click chemistry of DNA replication
Alfonso Gomez-Gonzalez, Patricia Burkhardt, Michael Bauer, Maarit Suomalainen, José-Maria Mateos, Morten Loehr, Nathan Luedtke, and Urs F. Greber (2024)
Sci Adv 10, eadq7483. 10.1126/sciadv.adq7483
https://pubmed.ncbi.nlm.nih.gov/39454009/
Preexisting cell state rather than stochastic noise confers high or low infection susceptibility of human lung epithelial cells to adenovirus
Anthony Petkidis, Maarit Suomalainen, Vardan Andriasyan, Abhyudai Singh & Urs F. Greber
mSphere, 2024, /doi.org/10.1128/msphere.00454-24
https://pubmed.ncbi.nlm.nih.gov/39315811/
A versatile automated pipeline for quantifying virus infectivity by label-free light microscopy and artificial intelligence
Anthony Petkidis, Vardan Andriasyan, Luca Murer, Romain Volle & Urs F Greber
Nat Commun, 2024, DOI: 10.1038/s41467-024-49444-1 https://pubmed.ncbi.nlm.nih.gov/38879641/
Gutless helper-dependent and first generation HAdV5 vectors have similar mechanical properties and common transduction mechanisms
Lars Thalmann, Natalia Martin-Gonzalez, Dominik Brücher, Andreas Plückthun, Pedro de Pablo, Maarit Suomalainen & Urs F. Greber
Human Gene Therapy, 2024, DOI: 10.1089/hum.2023.221
Machine learning for cross-scale microscopy of viruses
Anthony Petkidis, Vardan Andriasyan & Urs F Greber (2023)
Cell Reports Methods, doi.org/10.1016/j.crmeth.2023.100557
www.cell.com/cell-reports-methods/fulltext/S2667-2375(23)00201-1
Label-free microscopy for virus infections
Anthony Petkidis, Vardan Andriasyan & Urs F Greber (2023)
Microscopy (Oxf). 2023 Apr 20:dfad024.
https://doi.org/10.1093/jmicro/dfad024
Highlighted in SNSF News, Jan 20, 2023:
https://www.nfp78.ch/en/news/countering-covid-19-with-already-approved-active-substances/
Identification of broad anti-coronavirus chemical agents for repurposing against SARS CoV 2 and variants of concern.
L Murer, R Volle, V Andriasyan, A Petkidis, A Gomez-Gonzalez, L Yang, N Meili, M Suomalainen, M Bauer, D Sequeira, D Olszewski, F Georgi, F Kuttler, G Turcatti, UF Greber'
High-content, arrayed compound screens with rhinovirus, influenza A virus and herpes simplex virus infections
Olszewski D, Georgi F, Murer L, Andriasyan V, Kuttler F, Petkidis A, Witte R, Yakimovich A, Fischer L, Rozanova A, Yamauchi Y, Turcatti G, Greber UF (2022)
Sci Data. 2022 Oct 8;9(1):610. doi: 10.1038/s41597-022-01733-4
https://www.nature.com/articles/s41597-022-01733-4
Methylene blue, Mycophenolic acid, Posaconazole, and Niclosamide inhibit SARS-CoV-2 Omicron variant BA.1 infection of human airway epithelial organoids
Volle R, Murer L, Petkidis A, Andriasyan V, Savi A, Bircher C, Meili N, Fischer L, Sequeira DP, Mark DK, Gomez-Gonzalez A, Greber UF (2022)
Curr Res Microb Sci, 2022;3:100158
https://www.sciencedirect.com/science/article/pii/S2666517422000554
Sequence-specific features of short double-strand, blunt-end RNAs have RIG-I- and type 1 interferon-dependent or –independent anti-viral effects.
Kannan, A., Suomalainen, M., Volle, R., Bauer, M., Amsler, M., Trinh, H.V., Vavassori, S., Pachlopnik Schmid, J., Vilhena, G., Marín González, A., Perez, R., Franceschini, A., von Mering, C. Hemmi, S. & Greber, U.F. (2022).
Viruses, 14(7), 1407,
https://www.mdpi.com/1999-4915/14/7/1407/htm
Adenovirus Entry - Stability, Uncoating and Nuclear Import
Greber, UF & Suomalainen, M (2022)
Molecular Microbiology
10.1111/mmi.14909
PMID: 35434852
https://onlinelibrary.wiley.com/doi/10.1111/mmi.14909?af=R
Identification of broad anti-coronavirus chemical agents for repurposing against SARS CoV 2 and variants of concern.
L Murer, R Volle, V Andriasyan, A Petkidis, A Gomez-Gonzalez, L Yang, N Meili, M Suomalainen, M Bauer, D Sequeira, D Olszewski, F Georgi, F Kuttler, G Turcatti, UF Greber
Current Research in Virological Science, 3, 100019, doi.org/10.1016/j.crviro.2022.100019
PMID: 35072124
https://www.sciencedirect.com/science/article/pii/S2666478X22000010?via%3Dihub
A viral ubiquitination switch attenuates innate immunity and triggers nuclear import of virion DNA and infection.
Bauer M, Gomez-Gonzalez A, Suomalainen M, Schilling N, Hemmi S, Greber UF.
Sci Adv. 2021 Dec 17;7(51):eabl7150. doi: 10.1126/sciadv.abl7150. Epub 2021 Dec 17. PMID: 34919430
https://www.science.org/doi/10.1126/sciadv.abl7150
Featured in UZH News:
https://www.media.uzh.ch/en/Press-Releases/2021/Adenovirus-DNA-Transfer.html
Urs F Greber
Febs Letters, PMID: 34787897, DOI: https://doi.org/10.1002/1873-3468.14226
https://pubmed.ncbi.nlm.nih.gov/34787897
Murer L., Petkidis A., Vallet T., Vignuzzi M. & Greber U.F.
J Virol. 2021 Oct 27; JVI0106021; PMID: 34705560;DOI: 10.1128/JVI.01060-21
https://journals.asm.org/doi/10.1128/JVI.01060-21
Vardan Andriasyan, Artur Yakimovich, Anthony Petkidis, Fanny Georgi, Robert Witte, Daniel Puntener & Urs F. Greber
iScience, June 2021: doi.org/10.1016/j.isci.2021.102543
https://www.cell.com/action/showPdf?pii=S2589-0042(21)00511-3https://www.cell.com/action/showPdf?pii=S2589-0042(21)00511-3
Greber, U.F. & Gomez-Gonzalez, A. Adenovirus – a blueprint for gene delivery.
Curr Op Virol 2021, April 21, Vol 48, 49-56
www.sciencedirect.com/science/article/pii/S1879625721000225
Prasad, V. & Greber, U.F. The endoplasmic reticulum unfolded protein response – homeostasis, cell death and evolution in virus infections.
FEMS Microbiol Rev. 2021 Mar 25:fuab016. doi: 10.1093/femsre/fuab016
Suomalainen, M., Prasad, V., Kannan, A. & Greber, U.F. Cell-to-cell and genome-to-genome variability of Adenovirus transcription tuned by the cell cycle.
J Cell Sci. 2020 https://jcs.biologists.org/content/early/2020/09/10/jcs.252544.long
Georgi, F., Kuttler, F., Murer, L., Andriasyan, V., Witte, R., Yakimovich, A., Turcatti, G. & Greber, U. F. (2020) High-content image-based drug screen identifies a clinical compound against cell transmission of adenovirus.
Sci Data. 2020 Aug 12;7(1):265. doi: 10.1038/s41597-020-00604-0. PMID: 32788590
Georgi F, Andriasyan V, Witte R, Murer L, Hemmi S, Yu L, Grove M, Meili N, Kuttler F, Yakimovich A, Turcatti G, Greber UF. The FDA-approved drug Nelfinavir inhibits lytic cell-free, but not cell-associated non-lytic transmission of human adenovirus.
Antimicrob Agents Chemother. 2020 Jun 29: AAC.01002-20.
doi: https://aac.asm.org/content/early/2020/06/23/AAC.01002-20
Greber UF. 2020. Adenoviruses - Infection, pathogenesis and therapy. FEBS Lett doi:10.1002/1873-3468.13849
Prasad V, Suomalainen M, Jasiqi Y, Hemmi S, Hearing P, Hosie L, Burgert HG, Greber UF. 2020. The UPR sensor IRE1alpha and the adenovirus E3-19K glycoprotein sustain persistent and lytic infections. Nat Commun 11:1997. doi: 10.1038/s41467-020-15844-2
Bauer M, Flatt JW, Seiler D, Cardel B, Emmenlauer M, Boucke K, Suomalainen M, Hemmi S, & Greber UF (2019). The E3 Ubiquitin Ligase Mind Bomb 1 Controls Adenovirus Genome Release at the Nuclear Pore Complex. Cell Reports 29, 3785-3795. doi: 10.1016/j.celrep.2019.11.064
Stichling N, Suomalainen M, Flatt JW, Schmid M, Pacesa M, Hemmi S, Jungraithmayr W, Maler MD, Freudenberg MA, Plückthun, A, May T, Köster M, Fejer G & Greber UF (2018). Lung macrophage scavenger receptor SR-A6 (MARCO) is an adenovirus-type specific virus entry receptor. PloS Path 14(3):e1006914. doi: 10.1371/journal.ppat.1006914
Luisoni S, Suomalainen M, Boucke K, Tanner LB, Wenk MR, Guan XL, Grzybek M, Coskun U, & Greber UF (2015) Co-option of Membrane Wounding Enables Virus Penetration into Cells. Cell Host & Microbe 18 (1):75-85. doi:10.1016/j.chom.2015.06.006
Roulin, P., Lotzerich M, Tanner LB, Torta FT, van Kuppefeld F, Wenk MR, & Greber UF (2014). A Phosphatidylinositol 4-Phosphate and Cholesterol Counter-Current Model for the Formation of Rhinovirus Replication Compartments at ER-Golgi Interface. Cell Host & Microbe 16, 677-90. doi: 10.1016/j.chom.2014.10.003
Wang IH, Suomalainen M, Andriasyan V, Kilcher S, Mercer J, Neef A, Luedtke NW, & Greber UF (2013) Tracking viral genomes in host cells at single-molecule resolution. Cell Host & Microbe 14 (4):468-480. doi:10.1016/j.chom.2013.09.004
Strunze, S., Engelke, M.F., Wang, I.H., Puntener, D., Boucke, K., Schleich, S., Way, M., Schoenenberger, P., Burckhardt, C.J., and Greber, U.F. (2011). Kinesin-1-mediated capsid disassembly and disruption of the nuclear pore complex promote virus infection. Cell Host Microbe 10, 210-223. doi: 10.1016/j.chom.2011.08.010
Burckhardt CJ, Suomalainen M, Schoenenberger P, Boucke K, Hemmi S, & Greber UF (2011) Drifting motions of the adenovirus receptor CAR and immobile integrins initiate virus uncoating and membrane lytic protein exposure. Cell Host & Microbe 10 (2):105-117. doi:10.1016/j.chom.2011.07.006
Lütschg V, Boucke K, Hemmi S & Greber UF (2011). Chemotactic anti-viral cytokines promote infectious apical entry of human adenovirus into polarized epithelial cells. Nature Comm. 2, 391. doi: 10.1038/ncomms1391
Amstutz B, Gastaldelli M, Imelli N, Kälin S, Boucke K, Wandeler E, Mercer J, Hemmi S & Greber UF (2008). Subversion of CtBP1 controlled macropinocytosis by human Adenovirus serotype 3. EMBOJ. 27, 956-66. doi: 10.1038/emboj.2008.38
Trotman L, Mosberger N, Fornerod M, Stidwill RP & Greber UF (2001). Import of adenovirus DNA involves the nuclear pore complex receptor CAN/Nup214 and histone H1. Nature Cell Biol., 3, 1092-1100. doi: 10.1038/ncb1201-1092
Greber UF, Willetts M, Webster P, & Helenius A (1993) Stepwise dismantling of adenovirus 2 during entry into cells. Cell 75 (3):477-486. doi: 0092-8674(93)90382-Z [pii]
