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Environmental microbial communities are poorly explored for their chemistry. The study by Chandrashekhar Padhi and colleagues explored the algal-bacterial communities from lake Chilika in India, a large brackish water area. It reports a vast amount of reconstructed environmental genomes and over 2000 gene clusters used in biosynthetic pathways. Besides sampling and heterologous reconstitution of two silent Rheinheimera biosynthetic pathways, the study identifies new microbial compounds with potent protease inhibitory and antiviral activities. These post-translationally modified peptides are part of a underexplored class of compounds with potential antiviral effects.
Proc Natl Acad Sci U S A. 2024 Dec 3;121(49):e2409026121
https://pubmed.ncbi.nlm.nih.gov/39585984/
Broad-spectrum virus inhibitors are rare. The study here used human cell cultures and primary cells to uncover anti-viral activity of fibroblast growth factor receptor (FGFR) tyrosine kinase inhibitors. Low micromolar concentrations of several FGFR kinase inhibitors reduced herpes simplex virus 1 (HSV-1), encephalomyocarditis virus (EMCV), human coronavirus 229E (CoV-229) and influenza A virus (IAV) infections. Bioinformatics analyses of kinome data, targeted kinase assays, siRNA-mediated knock-down and additional pharmacological inhibitors demonstrated that Src family kinases, in particular Lyn but not FGFR kinase is crucial for HSV-1 infection at a post entry step. The results single out Lyn kinase as a potential target for the treatment of viral infections.
Cell Mol Life Sci. 2024 Dec 2;81(1):471. doi: 10.1007/s00018-024-05502-x
https://pubmed.ncbi.nlm.nih.gov/39621133/
Endocytic uptake of nonenveloped viruses or bacteria is well known to lead to rupture of the limiting endosomal membrane and pathogen release into the cytosol. The work by Schmidt et al. shows that cell entry of an enveloped virus, Kaposi sarcoma-associated herpesvirus (KSHV) is restricted by autophagy. Restriction is triggered by the interaction of the KSHV glycoprotein gH with its entry receptor EphA2, and seems to involve endosomal damage and the recruitment of galectin-8 to limit infection.
Cell Rep. 2024 Nov 26;43(12):115019
https://www.ncbi.nlm.nih.gov/pubmed/39602307
How many pathways can a virus take to enter into a cell? A recent paper by Ojha and collaborators in PLoS Pathogens shows that many vertebrate viruses can take at least two, a dynamin-dependent and a dynamin-independent one.
https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1012690
Farewell to Romain Volle. We are looking forward to staying in touch and continue to collaborate with him and the VetSuisse faculty of UZH.
A warm welcome to Céline Allera. In her Msc project Céline explores how the interaction of proteins with the viral DNA contributes to the variability of the infection outcome.
Farewell to Alfonso Gomez-Gonzalez. Best of luck for his postdoctoral project at MIT Boston, USA.
Congratulations to Julian Vogel and a brilliant defense of his Msc thesis 'Connecting Phenotype and Genotype: Measurement and Quantification of Infection-Phenotypes in recombinant Rhinoviruses'
Farewell to Dominik Olszweski and Michael Klingenbrunner. All the best to them for their future endeavors
A warm welcome to Jann Stäbler. In his Msc project Jann uses adenovirus infections to explore the molecular signatures of lytic and nonlytic infected human cell cultures
Congratulations to Alfonso Gomez-Gonzalez for defending his PhD thesis ‘Tracking Adenovirus DNA in Entry and Replication Provides Insight into Virion Uncoating and Assembly’
A warm welcome to Melanie Badasci. In her Msc studies Melanie uses telomerase reverse transcriptase-immortalized human dermal fibroblasts to probe how host gene activity is connected to the activity of the adenoviral E1A enhancer / promoter
Congratulations to Anthony Petkidis for defending his PhD thesis ‘Light Microscopy Combined with Computational Image Analysis Uncovers Virus-Specific Infection Phenotypes and Host Cell State Variability’
Congratulations to Dominik Olszewski’s PhD thesis defense ‘Full-Cycle Analysis of Viruses Reveals Effects of Sphingolipid Metabolites and Small Compounds on Transmission’
Congratulations to Silvio Hemmi and the team to a fine paper in Human Gene Therapy providing a range of new genetically engineered vectors for the adenovirus field.
https://pubmed.ncbi.nlm.nih.gov/37725579/
Congratulations to Daniela Sequeira’s PhD thesis defense ‘Full-Cycle Replication of Human Adenovirus in Primary T Cells
Farewell to Lucy Fischer who started as a technician in the Greber lab, and then took over the lab management in 2023. All the best to Lucy on her path to continued education.
Congratulations to a team of biophysicists / cell biologists / virologists from Madrid and Zurich for elucidating how the adenovirus linchpin protein V stabilizes the virion and decondenses the viral DNA genome. The work informs on mechanisms of DNA nuclear import in disease and therapy.
A cordial farewell to Nicole Meili. Nicole was the Greber lab manager for seven years, and has now taken a new appointment in clinical research lab management. We wish Nicole all the best.
A warm welcome to Sara Fernandes. Sara holds an Msc in Biomedical and Molecular Science Research from King’s College London, UK, and a diploma in Biomedical Analytics from the ‘Berufs- und Weiterbildungszentrum für Gesundheits- und Sozialberufe St.Gallen’, Switzerland. Sara is working as a research technician in the lab.
A warm welcome to Michael Klingenbrunner. Michael holds an Msc in Molecular Biology from the University of Vienna, Austria. Michael is working as a research technician in the lab.
A review article published on SARS-CoV-2 and dysfunction of vascular cells, together with colleagues from the Department of Vascular Surgery, University Hospital Zürich, Zürich, Switzerland.
A warm welcome to a new PhD student, Franziska Tomas joining the Greber lab with a Master Degree of Science in Biology from the University of Freiburg i. Br., Germany.
Congratulations to Daniela Policarpo Sequeira to winning the Best Poster / Flash Talk Award at the ‘2nd Swiss Young Microbiologists Symposium’ Zurich, July 8, 2022.
We congratulate Alfonso Gomez-Gonzalez for securing the Best Oral Presentation Award at the International Conference ‘Viruses 2022, At the Leading Edge of Virology Research’ April 5-8, held in online format.
Two new cell surface receptors for mouse Adenovirus type 1 and 3 identified! Congratulations to Silvio Hemmi and the team for a compelling study.
PLoS Pathogens doi.org/10.1371/journal.ppat.1010083
https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1010083
Congratulations to Otto Haller and an international team from China and Germany uncovering genetic links between the interferon stimulated gene MX1 and suceptibility of humans to avian influenza virus.
Science 2021, 373: 918-922. doi: 10.1126/science.abg5953
PhD Defense Luca Murer, July 23
Congratulations to Luca - beautiful new insights into the evolution of rhinovirus under chemical pressure
On-chip transporting arresting and characterizing individual nano-objects in biological ionic liquids’: a publication with the Poulikakos laboratory at ETH in the area of applied science and engineering.
Sci Adv. 2021 Jul 2;7(27):eabd8758. doi: 10.1126/sciadv.abd8758. Print 2021 Jul.
PMID: 34215575
https://advances.sciencemag.org/content/7/27/eabd8758
PubMed:
https://www.ncbi.nlm.nih.gov/pubmed/34215575
Congratulations to Anthony Petkidis and Daniela Sequeira for winning two poster prizes at the 14th International Adenovirus meeting in Toledo, Spain, in digital format.
Anthony discussed the concept of infection variability ‘Profiling transcriptomic single-cell heterogeneity in adenovirus-infected cells’, while Daniela presented her data on viral persistence ‘Towards understanding persistent human adenovirus infections’.
Welcome to a new PhD student. Cornelia Bircher joins the Greber lab with an Msc from the University of Bern in Molecular Life Sciences / Biochemistry/Chemical Biology.
Herpesvirus replication compartments and phase separation of a viral transcription factor: contribution to a study from M. Seyffert and colleagues in the Fraefel lab at UZH.
https://www.mdpi.com/1422-0067/22/9/4447
Welcome to a new PhD student in the lab. Alessandro Savi will explore rhinoviruses and coronaviruses, and their infections of human airway cells.
A collaboration with the laboratories of Plueckthun (UZH) and Zippelius (U-Basel) provides a versatile platform for the generation and assessment of high capacity gene therapy adenovirus vectors, so called helper-dependent or gutless vectors.
https://www.sciencedirect.com/science/article/pii/S2329050121000024?via%3Dihub
A Swiss National Science Foundation grant awarded to the Greber lab (UZH) on Coronavirus, a collaboration with the Turcatti lab (EPFL) and with support from the Thiel lab (U-Bern). Congratulations.
'Anti-CoV: Full-cycle high-throughput infection screen to identify clinical compounds with high repurposing potential against COVID-19'
An all atoms molecular dynamics simulation reveals bending of double-stranded RNA at AUAU tracts. Congrats to the UZH team with Maarit and Abhilash and the collaborators at University Autonoma Madrid!
https://academic.oup.com/nar/advance-article/doi/10.1093/nar/gkaa1128/6007656
Great collaboration with research groups at University of Bristol UK, in particular the Yamauchi lab in the School of Cellular & Molecular Medicine, and the Greber lab at UZH. Congrats! https://science.sciencemag.org/content/early/2020/10/19/science.abd3072?rss=1
Fanny Georgi, Defense
19st of June, Fanny successfully defended her PhD. Congratulations Dr. Georgi!
Congratulations to Georgi et al. for their publication. doi: https://doi.org/10.1128/AAC.01002-20
Congratulations to Michael and Dominik for their publication with Lang et al. DOI: 10.1038/s41467-020-15072-8
Congratulation to Bauer et al. for their publication.
doi: 10.1016/j.celrep.2019.11.064
The FEBS letter Special Issue “Adenoviruses Biology, Disease and Therapy” edited by Urs is published. Fanny’s representation of adenovirus spread makes it on the cover.
Romain Volle, block course teaching
For our future Masters and PhD`s, Romain gave the lecture and was responsible for the student management at the UZH Virology Bio blocks (Bio322 and Bio 615) in October/November 2019
Romain Volle, LS2 Meeting assessment
Evaluation of application for the “PI of tomorrow” co
Vardan’s manuscript ‘Deep learning of virus infections reveals mechanics of lytic cells’ was published on bioRxiv. Thank you to the co-authors Artur, Fanny, Anthony, Robert, Daniel and Urs!
Dominik Olszewski, speaker EMBO
Selected as a speaker, Dominik gave a talk at EMBO Workshop Lipids in Health and Disease in Dresden in September 2019
Anthony Petkidis and Dominik Olszewski, DMLS retreat planning
In August, Anthony and Dominik were responsible for the co-organisation of the scientific retreat of the MIM PhD program in Grindelwald
Michael Bauer, Defense
21st of August, Michael successfully defended his PhD. Congratulations Dr. Bauer!
Romain Volle, poster presentation
In March 2019 Romain showed his poster during the retreat at the Comprehensive Cancer Center Zurich.
Romain Volle, talk Virology
Also, Romain gave an oral presentation to the Société Française de Virologie (French Virology Society) in March 2019
Fanny presented her work at the EMBO workshop Visualizing Biological Data in Heidelberg.
Dominik Olszewski, speaker of the Flash talk
At the LS2 Meeting in February 2019, Dominik gave a Flash talk.
